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[Applause]

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[Music]

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this is a toxin that causes the pain

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what we do is oxidize it so it's no

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longer toxic and what we find is that

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and we find this by accident is that it

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has tremendous activity with respect to

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scarring in terms of preventing scars or

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ameliorating scars we will worry about

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the spectrum of targets we were

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interested in in this molecule as I say

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by accident because in a patient that we

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were treating using this molecule

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treating for something else we found it

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her scars disappeared her superficial

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scars are wondering how on earth could

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that possibly be so we started doing

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some big-time science and we know that

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streptomycin among other things is a

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potent anti-inflammatory agent yet down

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regulates pro-inflammatory genes that

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second one mmp9 is especially important

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over the last decade between eight and

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nine billion dollars have been spent by

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the pharmaceutical industry looking for

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products that down-regulate mmp9 because

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it's involved in so many diseases

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several of those products have made it

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to formal clinical trials and they have

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all failed because of toxicity again

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strep the licen though in our hands is

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not toxic well it down regulates the

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pro-inflammatory genes it up regulates

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the anti-inflammatory ones these we're

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not going to get into the science of but

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it's important that it

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is an anti-inflammatory product but it

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does a lot more than that one of the

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things it does is disrupt the balance

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between collagen and collagenase

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collagen is the primary protein in scars

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scars are not stable some of you have

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had scars from accidents or surgery or

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whatever that have been with you for

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decades those are changing every day

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although they look the same to you there

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there's a constant turnover of the

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collagen the collagenase the enzyme is

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breaking down old collagen new collagen

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is being is replacing the old we upset

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the balance in favor of collagenase so

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that the old collagen is broken down and

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it's replaced by more vital tissue we

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have we started with looking at a series

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of superficial scars and we found that

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external scars would all respond to slo

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therapy this is just a kind of an

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example of some of the types of scars

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that we looked at here's a more graphic

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example this is a face of a girl that

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just went through the windshield if you

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look closely and get oriented you can

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see there's her chin her teeth her nose

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has been torn off and displaced so she's

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in trouble this is her in the emergency

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room at the Medical University of South

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Carolina in in Charleston

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you can see she's gonna have a bit of a

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scar on her left cheek her nose is back

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in place there's gonna be some serious

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scarring there look at the angle of that

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tube it's ripped out the corner of her

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mouth gonna be some scars there and

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across her eyebrow also so she's gonna

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look like a pirate okay her mother was a

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nurse she started right away a nurse

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with us she got to the mother got to the

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emergency room started a solo therapy

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and there she is three weeks later and

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here she is a month after that last

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picture now you can see there's still a

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scar there that's going away it's not

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nearly what you might expect little or

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no scarring around the nose that corner

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of her mouth doesn't look too bad

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compared to what it did before

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jeez the good that'll be the next slide

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the point of all this is the important

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point is that nothing was given to her

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topically all right this is all systemic

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so there's nothing rubbed on her skin to

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make the scar go away or to prevent the

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scar so being clever scientists that we

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are we wondered well gosh if this is

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going systemically and working on

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external scars like this gals face what

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would happen with internal scars

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well first you ask what the heck are

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internal scars these are a few of the

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ones that we've treated successfully all

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of us have internal scars all the time

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and there is what's called the collagen

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theory of aging that would suggest that

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our longevity is determined by the

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collagen that accumulates in our body

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that is as a consequence of normal

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function of the organs there's constant

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inflammation which is followed by

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collagen deposition the collagen gets

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laid down cross-linked becomes less

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elastic that's what happens with

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cardiomyopathy for example that scar

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tissue forming in the heart the heart

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becomes less efficient as a consequence

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of that scar tissue and there is less

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efficient signaling between nodes of the

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heart likewise with the kidneys and the

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and the liver and so forth surgical

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adhesions big deal we had some fun with

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some patients that had circle surgical

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adhesions following gut surgery or a

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gynecological third surgery we know that

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one of the complications after those

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kinds of surgeries is often adhesions

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and what do you do for adhesions well

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the surgeon goes back in and cuts them

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out well guess what causes more

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adhesions so if we found that we could

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give streptomycin Oh in very low

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concentrations similar to the ones that

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dr. Ives was talking about and even

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lower and those adhesions would go away

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in two weeks no more surgery that's a

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big deal question came up to us more

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recently thinking back in the girl who

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went through the windshield could SL

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will be used to treat traumatic brain

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injury now clearly that's an internal

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type of scarring if it occurs but it's

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different than anything else we've ever

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done for a couple of reasons one is

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there's a question well let's first look

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at what traumatic brain injury is by

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definition its damage either temporary

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or permanent to the brain as a

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consequence of injury they're about a

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million and a half cases in this country

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per year of those 50,000 will die an

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80,000 are going to have some degree of

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permanent disability the most likely or

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the most common causes of traumatic

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brain injury in our country are

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accidents automobile bicycle pedestrian

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accidents second probably second is in

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the military with all the different

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things that the military personnel might

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be exposed to assault or a leading cause

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also we wondered still can we do

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anything about these kinds of injuries

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and the reasons are these we know that

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from the internal and external stars

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that seem to respond so successfully to

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slo therapy that those are those scars

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are involved with with collagen which

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comes from fibroblasts there are not

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fibroblasts in the brain and there's not

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collagen in the brain instead they're

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glial cells in the brain that people

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think have something to do with brain

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what might be called brain scarring so

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it's a question of collagen versus what

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well nobody really knows what another

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problem is you can't really scan and see

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by any imaging techniques that are

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available you can't see brain scars now

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there are four or five fda-approved

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methods for brain scans but none of them

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will show what we think a scar should

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look like so you can't see

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before-and-afters that's a lot different

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than internal and external scar external

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scars like the girls face it's easy

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doesn't measure internal scars you can

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also do we've published a couple papers

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using sonography for example with

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thoroughbred horses in Kentucky that

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we've done some work with and we can see

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very clearly nice objective measurements

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about what happens with scars as a

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consequence of SLO therapy you can watch

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them go away you can measure that you

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can't do that in the brain so what do we

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do instead we're going to have to focus

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on clinical outcomes well where are we

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going to find a few patients to fool

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around with

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guess what we'll go to some NFL players

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down in the Phoenix area and see if they

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might participate we started with six

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players one of them dropped out after

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just about two months disappeared we had

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no follow-up these others we followed

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for three years now these five and

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understand it's just a tiny tiny number

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but here are the original complaints not

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all the players had all these complaints

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but this is a pretty good cross-section

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of what happened it's interesting none

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of these would be a surprise to you

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especially to your psychiatrist and

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psychologists in the group none of these

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would be surprised a surprise for

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patients with repeated head injuries but

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all of these players were having real

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difficulty they couldn't hold jobs they

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were divorced they couldn't make it

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maintain a relationship with their

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girlfriends one of them is a very

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well-known sports broadcaster who was

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having trouble remembering names and

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numbers that's a problem for a

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sportscaster and he was certainly

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concerned about losing his job

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they couldn't concentrate they had

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headaches this is really really a tough

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situation so we asked these guys if they

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would be willing to take slo drops one

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drop four times a day one after each

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meal one before bed with all of our

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patients for whatever disorder or

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whatever therapeutic agent were using we

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find that for the first two weeks they

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are as compliant as can be after that to

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get bored taking drops and so forth so

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we're hoping that they would take at

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least two drops a day put the dart and

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drop a bottle by your toothbrush hope

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you do brush your teeth twice a day take

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one morning in one at night so they did

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within two weeks we usually saw a change

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or as a slight change they were

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reporting changes all the symptoms would

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resolved and the sportscaster had no

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trouble after two or three weeks

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remembering whatever you wanted to

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remember no more headaches it's not to

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say that all symptoms resolved in the

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equal rate of time or that all resolved

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completely but there was resolution to

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one degree or another of all of them and

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most of them now after three years are

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all resolved it was interesting that if

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the patient got excited about in their

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improvement and got tired of taking

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drops and stopped sometimes it would be

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a regression there would be a relapse

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but that relapse would be very quickly

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reversed by reinitiating the drops nice

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no adverse effects now typical with our

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group is if we have a new idea that we

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think would be useful clinically we try

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it on humans if it looks safe and

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there's some positive results then we do

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animal testing it's a little little bit

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backwards and then some people do but

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yeah that's worked out well for us so

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just in the last two or three months

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we've started working with a group from

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a university some of you have heard of

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it it's called Harvard that has an

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animal model for traumatic brain injury

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and they've agreed to cooperate with us

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and see what we can do what happens in

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this model is you induce brain injury

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you can do it at mild moderate or severe

276
00:12:42,750 --> 00:12:39,760
injury a pneumatically controlled

277
00:12:46,200 --> 00:12:42,760
metered force bang's of the mouse in the

278
00:12:48,000 --> 00:12:46,210
head you can do it once multiple times

279
00:12:49,620 --> 00:12:48,010
however you want to do it to try and

280
00:12:53,550 --> 00:12:49,630
reproduce what happens in a human

281
00:12:57,240 --> 00:12:53,560
situation so we had three groups of

282
00:12:59,579 --> 00:12:57,250
animals in our first round one we we

283
00:13:02,040 --> 00:12:59,589
damage and treat with SLO one group gets

284
00:13:05,010 --> 00:13:02,050
damaged and only saline then the third

285
00:13:08,160 --> 00:13:05,020
group gets into the retainer but is not

286
00:13:10,650 --> 00:13:08,170
damaged and then gets saline therapy

287
00:13:13,500 --> 00:13:10,660
okay so that's a sham control shame

288
00:13:14,820 --> 00:13:13,510
injury and these are the things we

289
00:13:16,260 --> 00:13:14,830
wanted to measure and again this is just

290
00:13:18,660 --> 00:13:16,270
a screen to see if it's worth pursuing

291
00:13:20,070 --> 00:13:18,670
just like really the five football

292
00:13:20,940 --> 00:13:20,080
players were a screen to see if it's

293
00:13:23,190 --> 00:13:20,950
worth pursuing this

294
00:13:26,070 --> 00:13:23,200
notion of treating traumatic brain

295
00:13:28,080 --> 00:13:26,080
injury with SLO so we wanted a major

296
00:13:29,460 --> 00:13:28,090
balanced spatial and performance memory

297
00:13:30,840 --> 00:13:29,470
and then look at the astrology

298
00:13:35,850 --> 00:13:30,850
sacrificed the animals and see what's

299
00:13:39,740 --> 00:13:35,860
happening in the brain here's what's

300
00:13:43,200 --> 00:13:39,750
happening all parameters improved

301
00:13:45,510 --> 00:13:43,210
balance improved in ten days after the

302
00:13:48,150 --> 00:13:45,520
after the start of therapy this next

303
00:13:50,730 --> 00:13:48,160
point is really interesting the treated

304
00:13:52,890 --> 00:13:50,740
animals improve with balance so that was

305
00:13:55,620 --> 00:13:52,900
even better than the Sham controls that

306
00:13:56,850 --> 00:13:55,630
had never been injured you know I don't

307
00:13:58,800 --> 00:13:56,860
know how you go figure that it doesn't

308
00:13:59,490 --> 00:13:58,810
really matter but the point is they were

309
00:14:01,650 --> 00:13:59,500
as good as new

310
00:14:05,940 --> 00:14:01,660
so to speak if not a little bit better

311
00:14:07,830 --> 00:14:05,950
than new memory parameters have improved

312
00:14:10,530 --> 00:14:07,840
and again they're back to normal after

313
00:14:12,570 --> 00:14:10,540
about three weeks of therapy and this is

314
00:14:16,320 --> 00:14:12,580
memory for both spatial and performance

315
00:14:18,540 --> 00:14:16,330
memory and this slide is about ten days

316
00:14:23,280 --> 00:14:18,550
old so that last dot point is incorrect

317
00:14:30,300 --> 00:14:23,290
we do have histology report results back

318
00:14:33,060 --> 00:14:30,310
now and the the result is that there is

319
00:14:38,010 --> 00:14:33,070
decrease gliosis in the treated animals

320
00:14:40,170 --> 00:14:38,020
now gliosis is defined as being an

321
00:14:42,480 --> 00:14:40,180
accumulation of nervous tissue in the

322
00:14:45,180 --> 00:14:42,490
central nervous system we're not

323
00:14:46,290 --> 00:14:45,190
convinced that that definition is

324
00:14:49,770 --> 00:14:46,300
accurate anymore

325
00:14:52,530 --> 00:14:49,780
we think that gliosis is going to refer

326
00:14:55,170 --> 00:14:52,540
to the accumulation really of brain scar

327
00:14:59,580 --> 00:14:55,180
tissue in the central nervous system as

328
00:15:05,210 --> 00:14:59,590
a consequence of injury and we're seeing

329
00:15:11,270 --> 00:15:08,340
again even with the mice no adverse

330
00:15:14,850 --> 00:15:11,280
effects so we have had patients with

331
00:15:18,000 --> 00:15:14,860
external and then internal scars on this

332
00:15:20,460 --> 00:15:18,010
therapy of slo for years and we've never

333
00:15:23,100 --> 00:15:20,470
seen an adverse effect we now have the

334
00:15:26,070 --> 00:15:23,110
traumatic brain injury patients who are

335
00:15:28,500 --> 00:15:26,080
few and Forwell three years for the

336
00:15:30,360 --> 00:15:28,510
football players no adverse effects and

337
00:15:32,700 --> 00:15:30,370
we have done animal work just on the

338
00:15:34,040 --> 00:15:32,710
toxicology and we have gone up to five

339
00:15:36,320 --> 00:15:34,050
thousand times our No

340
00:15:38,889 --> 00:15:36,330
dose given IV and still no adverse

341
00:15:41,150 --> 00:15:38,899
effects so er confident is fairly safe

342
00:15:43,100 --> 00:15:41,160
this is what we have planned in the near

343
00:15:46,610 --> 00:15:43,110
future we want to continue our

344
00:15:49,370 --> 00:15:46,620
collaborative work increase the size of

345
00:15:51,019 --> 00:15:49,380
the mouse experiments we want to look at

346
00:15:55,280 --> 00:15:51,029
animals with varying degrees of injury

347
00:15:58,490 --> 00:15:55,290
and we also want to have various start

348
00:16:00,079 --> 00:15:58,500
times for SLO therapy that is to say t0

349
00:16:01,970 --> 00:16:00,089
right after the time of injury maybe

350
00:16:05,420 --> 00:16:01,980
even before the time of injury and then

351
00:16:07,670 --> 00:16:05,430
30 60 90 days after injury to start

352
00:16:10,940 --> 00:16:07,680
therapy I should mention that there is

353
00:16:13,120 --> 00:16:10,950
an advantage in humans to starting SLO

354
00:16:15,199 --> 00:16:13,130
therapy before surgery for example

355
00:16:16,550 --> 00:16:15,209
knowing now that we've had years of

356
00:16:19,490 --> 00:16:16,560
experience and the physicians on our

357
00:16:22,730 --> 00:16:19,500
group will consistently report that

358
00:16:25,220 --> 00:16:22,740
patients on SLO therapy before surgery

359
00:16:27,650 --> 00:16:25,230
will heal more quickly than would be

360
00:16:30,410 --> 00:16:27,660
anticipated they need very little in the

361
00:16:32,690 --> 00:16:30,420
way of analgesics and you don't get any

362
00:16:37,639 --> 00:16:32,700
complications that would be associated

363
00:16:38,990 --> 00:16:37,649
with untoward scar tissue we're going to

364
00:16:41,260 --> 00:16:39,000
expand the human treated population

365
00:16:44,030 --> 00:16:41,270
we've had to turn away football players

366
00:16:46,670 --> 00:16:44,040
that want to get into this study we're

367
00:16:49,280 --> 00:16:46,680
working with a little more formal way

368
00:16:53,269 --> 00:16:49,290
now are setting up to where we will have

369
00:16:57,620 --> 00:16:53,279
we hope nearly a hundred patients

370
00:17:01,040 --> 00:16:57,630
involved and we badly need to do more in

371
00:17:03,440 --> 00:17:01,050
the way of full psychological and

372
00:17:05,240 --> 00:17:03,450
physiological work ups before during and

373
00:17:07,189 --> 00:17:05,250
after therapy what I've told you about

374
00:17:09,409 --> 00:17:07,199
our TBI work is really screening work

375
00:17:11,620 --> 00:17:09,419
but all the screening looks positive so

376
00:17:14,419 --> 00:17:11,630
we're we're fairly excited about this

377
00:17:17,659 --> 00:17:14,429
because as far as we know there's

378
00:17:20,150 --> 00:17:17,669
nothing else in the world literally that

379
00:17:22,730 --> 00:17:20,160
addresses this problem it is a big

380
00:17:24,740 --> 00:17:22,740
problem I've talked with directors of

381
00:17:27,530 --> 00:17:24,750
veteran administration hospitals who

382
00:17:28,909 --> 00:17:27,540
said who say come to our hospitals we

383
00:17:31,280 --> 00:17:28,919
have whole Ward's of people who can work

384
00:17:34,730 --> 00:17:31,290
with so this is what we are up to the

385
00:17:36,830 --> 00:17:34,740
last thing we want to do not last thing

386
00:17:38,990 --> 00:17:36,840
on a dot points not necessarily last in

387
00:17:41,510 --> 00:17:39,000
terms of importance is we're interested

388
00:17:44,480 --> 00:17:41,520
in what happens with SLO treatment for

389
00:17:47,600 --> 00:17:44,490
what might be called normal age-related

390
00:17:51,110 --> 00:17:47,610
dementia will it do anything

391
00:17:53,539 --> 00:17:51,120
we know that with normal aging the brain

392
00:17:55,430 --> 00:17:53,549
shrinks that's been nicely measured

393
00:17:57,799 --> 00:17:55,440
there's a question as to whether that

394
00:17:59,810 --> 00:17:57,809
shrinkage is directly associated with

395
00:18:02,450 --> 00:17:59,820
loss of cognition memory and things of

396
00:18:05,299 --> 00:18:02,460
that sort we want to know what happens

397
00:18:07,880 --> 00:18:05,309
with slo to the brain of the so-called

398
00:18:10,430 --> 00:18:07,890
normal person so that's the normal

399
00:18:20,050 --> 00:18:10,440
elderly person that's what we have in

400
00:18:24,830 --> 00:18:22,790
thank you John questions for John a

401
00:18:28,130 --> 00:18:24,840
quick anecdote as people go up to the

402
00:18:30,740 --> 00:18:28,140
mic I went through a glass window a

403
00:18:34,970 --> 00:18:30,750
glass door when I was 10 years old that

404
00:18:37,310 --> 00:18:34,980
was a few weeks ago and John gave me

405
00:18:39,050 --> 00:18:37,320
some s I had a big scar across my wrist

406
00:18:42,110 --> 00:18:39,060
I almost bled to death they couldn't

407
00:18:47,080 --> 00:18:42,120
stitch me back together I'll show you

408
00:18:56,950 --> 00:18:47,090
[Music]

409
00:19:00,920 --> 00:18:56,960
scars : I was reluctant to accept your

410
00:19:02,780 --> 00:19:00,930
it's interesting question individual

411
00:19:04,820 --> 00:19:02,790
physicians and veterinarians have been

412
00:19:06,320 --> 00:19:04,830
very eager to embrace it because they

413
00:19:08,720 --> 00:19:06,330
know number one it's safe and there are

414
00:19:10,340 --> 00:19:08,730
not many alternatives the Food and Drug

415
00:19:12,920 --> 00:19:10,350
Administration has been a little bit

416
00:19:17,720 --> 00:19:12,930
resistant because it's so darn new and a

417
00:19:20,090 --> 00:19:17,730
different approach but I think in in not

418
00:19:22,640 --> 00:19:20,100
being flippant to your question the

419
00:19:25,790 --> 00:19:22,650
mainstream has not had an opportunity to

420
00:19:28,790 --> 00:19:25,800
evaluate it to see we have published a

421
00:19:30,470 --> 00:19:28,800
few papers about this we do get requests

422
00:19:33,350 --> 00:19:30,480
every time we publish we get requests

423
00:19:36,070 --> 00:19:33,360
from practitioners to try it you know on

424
00:19:38,330 --> 00:19:36,080
patients not as part of any study

425
00:19:40,340 --> 00:19:38,340
frankly I think once we get it through

426
00:19:41,870 --> 00:19:40,350
the FDA and we do have what's called an

427
00:19:43,820 --> 00:19:41,880
IND in place with the Food and Drug

428
00:19:45,140 --> 00:19:43,830
Administration now I think once we get

429
00:19:46,610 --> 00:19:45,150
that through I don't I don't believe

430
00:19:48,830 --> 00:19:46,620
we're going to have much resistance in

431
00:19:53,350 --> 00:19:48,840
part because there just isn't much else

432
00:19:55,610 --> 00:19:53,360
and we have an ever older population and

433
00:19:59,230 --> 00:19:55,620
people are getting afraid and I think we

434
00:20:03,410 --> 00:19:59,240
could help yes sir

435
00:20:05,000 --> 00:20:03,420
thank you it's really fascinating but

436
00:20:09,560 --> 00:20:05,010
I'm wondering given what you did what

437
00:20:11,140 --> 00:20:09,570
you have told us about the the interest

438
00:20:15,830 --> 00:20:11,150
that people have in getting in on these

439
00:20:19,070 --> 00:20:15,840
experiments it seems to me that that

440
00:20:22,700 --> 00:20:19,080
further torturing and sacrificing of the

441
00:20:26,330 --> 00:20:22,710
animals is marginal in terms of its

442
00:20:28,750 --> 00:20:26,340
morality and I think the fact that we

443
00:20:31,030 --> 00:20:28,760
use the word sacrifice instead of kill

444
00:20:33,340 --> 00:20:31,040
indicates that we're trying to

445
00:20:36,190 --> 00:20:33,350
hope that in some sort of a religious

446
00:20:38,500 --> 00:20:36,200
patina so I wonder whether whether it be

447
00:20:41,110 --> 00:20:38,510
possible for you to consider not doing

448
00:20:45,130 --> 00:20:41,120
that part of it it's an interesting

449
00:20:50,230 --> 00:20:45,140
point and our interest is helping

450
00:20:54,880 --> 00:20:50,240
patients unfortunately in order for us

451
00:20:57,010 --> 00:20:54,890
as a dinky company to get something that

452
00:21:01,270 --> 00:20:57,020
as the previous question asked about

453
00:21:05,110 --> 00:21:01,280
getting something accepted the FDA and

454
00:21:07,270 --> 00:21:05,120
others asked for preclinical proof that

455
00:21:10,030 --> 00:21:07,280
this works and what they mean by

456
00:21:13,270 --> 00:21:10,040
preclinical is animal experimentation

457
00:21:14,950 --> 00:21:13,280
and you're right

458
00:21:17,500 --> 00:21:14,960
if these football players are getting

459
00:21:20,050 --> 00:21:17,510
better and other patients are doing well

460
00:21:22,210 --> 00:21:20,060
why on earth do you need to do any

461
00:21:24,790 --> 00:21:22,220
animal work from a practical standpoint

462
00:21:28,600 --> 00:21:24,800
you don't from a regulatory standpoint

463
00:21:30,610 --> 00:21:28,610
you do and we're stuck it's it's a

464
00:21:34,180 --> 00:21:30,620
bummer but that's just the way it is I'm

465
00:21:35,710 --> 00:21:34,190
afraid John could you tell answer two

466
00:21:37,810 --> 00:21:35,720
questions one could you give me the

467
00:21:39,750 --> 00:21:37,820
molecular weight of SLO and two what is

468
00:21:43,150 --> 00:21:39,760
the dose you're giving to people yeah

469
00:21:47,980 --> 00:21:43,160
molecular weights about sixty nine

470
00:21:52,330 --> 00:21:47,990
thousand Dalton and the dose a dose is

471
00:21:54,220 --> 00:21:52,340
about I can't tell you I will tell you

472
00:21:58,480 --> 00:21:54,230
but this is gonna be false and I'll tell

473
00:22:03,010 --> 00:21:58,490
you why we when we make up the medicine

474
00:22:06,790 --> 00:22:03,020
it's made up to a dose of about 1.6 and

475
00:22:09,550 --> 00:22:06,800
nanograms per dose and I say that that

476
00:22:13,030 --> 00:22:09,560
is false because the vast majority of

477
00:22:16,720 --> 00:22:13,040
the SLO that goes into the vial adheres

478
00:22:19,150 --> 00:22:16,730
to the glass so we have spent two years

479
00:22:21,430 --> 00:22:19,160
and a bunch of numbers of hundreds of

480
00:22:23,980 --> 00:22:21,440
thousands of dollars to develop what's

481
00:22:26,560 --> 00:22:23,990
called a release assay which the FDA

482
00:22:28,210 --> 00:22:26,570
rightly requires to prove that what was

483
00:22:31,900 --> 00:22:28,220
in the vial at the start is still there

484
00:22:32,860 --> 00:22:31,910
at the end and for us it's not so we

485
00:22:34,420 --> 00:22:32,870
have to go with what's called a

486
00:22:37,560 --> 00:22:34,430
functional assay and as dr. Ives

487
00:22:39,850 --> 00:22:37,570
mentioned we're we're way below

488
00:22:40,820 --> 00:22:39,860
Avogadro's number I do believe in what's

489
00:22:42,710 --> 00:22:40,830
left in

490
00:22:46,070 --> 00:22:42,720
by oh that's why we're going to have to

491
00:22:48,529 --> 00:22:46,080
go to a functional assay instead of the

492
00:22:55,549 --> 00:22:48,539
typical chemical assay for for dosing

493
00:22:59,779 --> 00:22:55,559
thank you hello I don't know any of the

494
00:23:02,389 --> 00:22:59,789
a lot about 22 brain injury but there's

495
00:23:07,810 --> 00:23:02,399
a fellow who I a client that I work with

496
00:23:10,460 --> 00:23:07,820
who in a psychiatric program who has

497
00:23:13,129 --> 00:23:10,470
brain injury from a child that was hit

498
00:23:16,909 --> 00:23:13,139
by a car or something and he hears

499
00:23:19,039 --> 00:23:16,919
voices and his family says that that he

500
00:23:23,419 --> 00:23:19,049
said that the voices began after the

501
00:23:26,060 --> 00:23:23,429
injury number one is that a symptom and

502
00:23:29,720 --> 00:23:26,070
number two do you have you experienced

503
00:23:31,789 --> 00:23:29,730
any alleviation of that symptom we have

504
00:23:34,279 --> 00:23:31,799
and even in the small number of football

505
00:23:37,039 --> 00:23:34,289
players we have one of the reasons why a

506
00:23:39,440 --> 00:23:37,049
couple of them had trouble holding jobs

507
00:23:41,360 --> 00:23:39,450
or maintaining interpersonal

508
00:23:43,610 --> 00:23:41,370
relationships was just that sort of

509
00:23:45,919 --> 00:23:43,620
problem and that's not I don't mean to

510
00:23:49,279 --> 00:23:45,929
imply for a second that SLO is the

511
00:23:51,830 --> 00:23:49,289
panacea for all brain problems but if

512
00:23:53,960 --> 00:23:51,840
they are ones caused by traumatic brain

513
00:24:00,000 --> 00:23:53,970
injury at least we have a chance to help

514
00:24:05,030 --> 00:24:02,880
well I've got one small bottle and we

515
00:24:08,299 --> 00:24:05,040
can take bids